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Isolation and Culture of Dental Pulp Stem Cells from a Supernumerary Tooth

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¾È¼Ò¿¬ ( An So-Youn ) - ¿ø±¤´ëÇб³ Ä¡°ú´ëÇÐ ¼Ò¾ÆÄ¡°úÇб³½Ç

Abstract

Áٱ⼼Æ÷´Â ¹ÌºÐÈ­ »óÅÂÀÇ ¼¼Æ÷·Î Áö¼ÓÀûÀÎ ÀÚ°¡ ºÐ¿­´É°ú ƯÁ¤ ¼¼Æ÷·Î ºÐÈ­ ÇÒ ¼ö ÀÖ´Â ºÐÈ­´ÉÀ» Áö´Ï°í ÀÖÀ¸¸ç ÀÌ·¯ÇÑ Æ¯¼ºÀ¸·Î ¸»¹Ì¾Ï¾Æ ³­Ä¡º´ÀÇ »õ·Î¿î ÀåÀ» ¿­ °ÍÀ̶ó´Â ±â´ë°¨À» ¾ò°í ÀÖ´Ù. Áï, ¼¼Æ÷ÀÌ½Ä ÈÄ Æ¯Á¤ ¼¼Æ÷·Î ºÐÈ­ À¯µµ¸¦ ½ÃÄÑ ±âÁ¸ÀÇ Ä¡·á ¹æ¹ýÀ¸·Î´Â Ä¡·á°¡ µÇÁö ¾Ê¾Ò´ø ¸¹Àº ÀÇÇÐÀû ³­Á¦µéÀ» Ç® ¼ö ÀÖ´Â ¿­¼èÀÎ °ÍÀÌ´Ù. Ä¡¾Æ´Â Æò»ý¿¡ °ÉÃÄ ¹ß°ÅµÇ´Â Á¶Á÷À¸·Î Ä¡¾ÆÁٱ⼼Æ÷´Â ¾ò±â°¡ ºñ±³Àû ½¬¿ö¼­ ´Ù¸¥ ¼ºÃ¼Áٱ⼼Æ÷µéº¸´Ù ´õ ³ôÀÌ Æò°¡µÇ°í ÀÖ´Ù. °úÀ×Ä¡´Â Àü ¼¼°è ´Ù¾çÇÑ ÀÎÁ¾¿¡¼­ ¹ß°ßµÇ´Â Áß¿äÇÑ ÀÓ»óÀû ÁúȯÀÌ´Ù. °úÀ×Ä¡ÀÇ À¯º´À²Àº °ü·Ã ¿¬±¸ º¸°í¼­¸¶´Ù ´Ù¾çÇϳª ¼Ò¾ÆÄ¡°ú ÀÇ»çµéÀÇ °æ¿ì ÀÓ»ó¿¡¼­ ÀÚÁÖ °úÀ×Ä¡¸¦ ¹ß°ÅÇÏ°í ÀÖ´Ù. ±×·¯³ª, ÇöÀç±îÁö ÁøÇàµÈ Áٱ⼼Æ÷ °ü·Ã ¿¬±¸µéÀ» »ìÆ캸¸é °úÀ×Ä¡ÀÇ Áٱ⼼Æ÷¿¡ °üÇÑ º¸°í´Â ¾øÀ¸¸ç, ÀÌ´Â Áٱ⼼Æ÷·Î ÀÌ¿ë °¡´ÉÇÑ Áß¿äÇÑ ÀÚ¿øÀ» ÆıâÇÏ°í ÀÖ´Â °ÍÀº ¾Æ´ÑÁö Àǹ®ÀÌ »ý±ä´Ù. ±×·¯¹Ç·Î º» ¿¬±¸´Â °úÀ×Ä¡¿¡ Æ÷ÇÔµÈ ¼¼Æ÷°¡ Áٱ⼼Æ÷ÀÇ Æ¯Â¡À» °¡Áö°í ÀÖ´ÂÁö¸¦ ¹àÇô³»±â À§ÇØ ÁøÇàµÇ¾ú´Ù.

Dental Pulp Stem Cells are superior to other types of adult stem cell. Because of teeth are easy to access and are extracted throughout life. A supernumerary tooth is an important clinical problem found in various populations of the world. The incidence of supernumerary teeth varies depending on the literature source. Pediatric dentists are routinely extracted them. However, no studies have been reported regarding Dental Pulp stem cells in a supernumerary tooth, and we failed to note that a valuable source of human stem cell. Herein, we tried to show that a supernumerary tooth contains cells that display the characteristic features of stem cells.

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Degenerative medicine;Dental Pulp Stem Cell;Primary tooth;Supernumerary tooth;Tissue engineering

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